目的 系统整合肝移植术后代谢综合征患者生活方式管理的最佳证据，为临床构建规范化干预体系提供科学支撑。方法 依据“5S”金字塔模型实施系统检索，涵盖计算机决策支持系统、国内外权威数据库、指南发布平台及国际专业协会官网。文献类型包括临床决策、指南、专家共识、证据总结及系统评价。检索时限为建库至2024年9月22日。由3名研究者独立进行文献质量评价并提取与整合证据。结果 共纳入12篇文献，包括临床决策1篇、循证指南5篇、系统评价2篇、专家共识4篇，从高危人群、干预时机、动态评估、多学科协作、目标设定、饮食调控、运动处方、合理用药与监测、健康行为指导、随访监测、自我健康管理11个方面总结出29条证据。结论 总结的最佳证据可为医护人员、患者及家属对肝移植术后代谢综合征患者生活方式管理提供参考。

Objective To systematically integrate the best evidence for lifestyle management in patients with liver transplantation metabolic syndrome (LTMS),and to provide scientific support for the clinical construction of a standardized intervention system.Methods A systematic retrieval was conducted in accordance with the 5S pyramid model,covering computerized decision support systems,authoritative databases at home and abroad,guideline publishing platforms,and official websites of international professional associations.The types of literature included clinical decision documents,evidence-based guidelines,expert consensuses,evidence summaries,and systematic reviews.The retrieval period was from the inception to September 22,2024.Three researchers independently conducted literature quality evaluation,and extracted and integrated the evidence.Results A total of 12 articles were included,with 1 clinical decision,5 evidence-based guidelines,2 systematic reviews,and 4 expert consensuses.A total of 29 pieces of evidence were summarized from 11 aspects:high-risk population,intervention timing,dynamic assessment,multidisciplinary collaboration,goal setting,dietary regulation,exercise prescription,rational medication and monitoring,health behavior guidance,follow-up monitoring,and self-health management. Conclusions The summarized best evidence can provide a reference for medical staff,patients and their families in the lifestyle management of patients with LTMS.

R47

国家自然科学基金青年项目（72204053）；复旦大学附属中山医院护理部循证实践项目（HLXZ202408）