目的 探讨沉浸式虚拟现实认知训练对社区轻度认知障碍患者的应用效果，为延缓疾病进展、提高患者的生活质量提供现实依据。方法 2021年3-8月，采用招募的方式，选取某社区轻度认知障碍患者97例为研究对象，按随机数字表法将其分为试验组（49例）和对照组（48例）。试验组接受沉浸式虚拟现实认知干预，对照组接受健康教育，两组的干预均持续12周，3次/周，30~45 min/次。于干预前后采用蒙特利尔认知评估量表（Montreal cognitive assessment scale,MoCA）、简明精神状态量表（mini-mental state examination,MMSE）、听觉词语学习测验（auditory verbal learning test,AVLT）、形状连线测验（shape trails test,STT）、老年抑郁量表（geriatric depression scale,GDS）对两组患者进行评估。结果 两组各有41例完成研究。干预前，两组患者的MoCA、MMSE、AVLT、STT、GDS等评分差异均无统计学意义(均P＞0.05)；干预后，试验组MoCA、MMSE、AVLT（延时、再认）等评分均优于对照组，差异均有统计学意义（均P＜0.05）。结论 沉浸式虚拟现实认知训练可有效改善社轻度认知障碍患者认知功能与情绪状态，具有可行性和适用性。

Objective To explore the intervention effects of immersive virtual reality (IVR) cognitive training for community-dwelling patients with mild cognitive impairment (MCI),and to provide practical evidence for delaying disease progression and improving patients’ quality of life.Methods From March to August 2021,97 community-dwelling MCI patients were recruited and randomly assigned to either the experimental group (n=49) receiving IVR cognitive training or the control group (n=48) receiving health education.Both intervention lasted 12 weeks (3 sessions/week,30-45 minutes/session).Assessment was conducted before and after intervention with Montreal cognitive assessment (MoCA),mini-mental state examination (MMSE),auditory verbal learning test (AVLT),shape trails test (STT),and geriatric depression scale (GDS).Results 41 participants completed the study in each group.Before the intervention,there were no statistically significant differences in MoCA,MMSE,AVLT,STT,and GDS scores between the 2 groups (all P＞0.05).Post-intervention,the experimental group demonstrated significantly better performance in MoCA,MMSE,and AVLT (delayed recall and recognition) scores compared to controls (all P＜0.05).Conclusions IVR cognitive training effectively improves cognitive function and emotional status in community-dwelling MCI patients,demonstrating feasibility and applicability.

R473.59

福建省科技计划项目（2020Y9021）