目的 探讨恐惧疾病进展在乳腺癌患者创伤后应激障碍与创伤后成长间的中介效应。方法 采用便利抽样法，选取长沙市某三级甲等医院住院的364例乳腺癌患者为研究对象，使用一般资料调查表、简体中文版创伤后成长评定量表、创伤后应激障碍平民版量表及恐惧疾病进展量表简版对其进行调查。结果 乳腺癌患者的创伤后成长得分为[65.0（56.0，73.0）]分、创伤后应激障碍得分为[26.0（23.0，33.0）]分、恐惧疾病进展得分为[30.0（25.0，36.0）]分,三者之间均呈正相关(均P＜0.01)。恐惧疾病进展在创伤后应激障碍与创伤后成长间发挥中介作用，中介效应比为70.50%。结论 恐惧疾病进展可通过创伤后应激障碍影响乳腺癌患者的创伤后成长水平。护理人员应帮助患者直面疾病恐惧，激发其抗争意识，促进心理成长。

Objective To explore the mediating effect of fear of disease progression between post-traumatic stress disorder and post-traumatic growth in breast cancer patients.Methods A cross-sectional survey was conducted among 364 breast cancer inpatients in a tertiary A hospital in Changsha using general information questionnaire,Chinese-Posttraumatic Growth Inventory,Post-Traumatic Stress Disorder Checklist-Civilian,and Fear of Progression Questionnaire-Short Form.Results The scores were 65.0(56.0，73.0) for post-traumatic growth,26.0(23.0，33.0) for post-traumatic stress disorder,and 30.0(25.0，36.0) for fear of progression.Positive correlations were found among all three variables(all P＜0.01).Fear of disease progression mediated the relationship between post-traumatic stress disorder and post-traumatic growth,with a mediating effect ratio of 70.50%.Conclusions Fear of disease progression may influence post-traumatic growth through post-traumatic stress disorder in breast cancer patients.Nurses should guide patients to properly confront disease-related fears and stimulate their fighting spirit to promote positive psychological growth.

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湖南省自然科学基金资助项目（2024JJ5300）；湖南省教育厅科学研究优秀青年项目（24B0367）；湖南中医药大学研究生创新课题（2024CX185）