目的 探讨老年血液肿瘤患者衰弱与抑郁的相关性，为临床制订相关干预措施提供理论依据。 方法 采用便利抽样法，选取2023年4—11月国内17家医院收治的505例老年血液肿瘤患者为研究对象。使用一般资料调查表、老年筛查工具-8问卷（ geriatric 8 geriatric screening tool，G-8）、简版老年抑郁量表（15-item geriatric depression scale，GDS-15）收集资料。 结果 老年血液肿瘤患者G-8总分为12(10,14)分，GDS-15总分为6(5,8)分，G-8总分与GDS-15总分呈负相关（ r=-0.124， P =0.005）。GDS-15总分、家庭人均月收入、有基础疾病以及是血液肿瘤初治患者为老年血液肿瘤患者衰弱的主要影响因素 （ P ＜0.05），共同解释了总变异的10.1%。 结论 老年血液肿瘤患者衰弱与抑郁相关，建议护理人员从衰弱角度识别抑郁倾向，及时干预以降低抑郁发生率。

Objective To explore the correlation between frailty and depression in elderly patients with hematological malignancies,so as to provide a theoretical basis for the development of relevant clinical intervention measures.Methods A convenience sampling method was employed to select 505 elderly patients with hematological malignancies admitted to the hematology departments of 17 domestic hospitals from April 2023 to November 2023 as the subjects of the study.Data were collected using a general information questionnaire,the Geriatric 8 geriatric screening tool(G-8),and the 15-item Geriatric Depression Scale (GDS-15).Results Elderly patients with hematological malignancies had a G-8 total score of 12(10,14) points, and a GDS-15 total score of 6(5,8) points.The total scores of the G-8 were negatively correlated with the total scores of the GDS-15 ( r=-0.124,P =0.005).Multiple linear regression analysis indicated that the total score of the GDS-15,monthly per capita household income,presence of underlying diseases,and being a newly diagnosed patient with hematological malignancies were the main factors affecting frailty in elderly patients with hematological malignancies ( P＜0.05),collectively explaining 10.1% of the total variance in G-8 scores.Conclusions There is a correlation between frailty and depression in elderly patients with hematological malignancies.Nursing staff can identify patients with depression from the perspective of frailty and provide timely interventions to reduce the incidence of depression in elderly patients with hematological malignancies.

北京协和医学院中央高校基本科研业务费资助(3332023063)