目的 总结危重症患者骨髓腔输液 (intraosseous infusion，IO)管理的最佳证据，为临床护理实践提供参考。方法 计算机检索相关指南网站及英国医学杂志最佳临床实践、Up To Date、Embase、Cochrane Library、PubMed、CINAHL、中国知网、万方数据库、维普数据库中关于危重症患者IO管理的指南、临床决策、证据总结、专家共识、系统评价，检索时限为建库至2023年12月。由2名研究人员独立筛选文献和质量评价，并根据主题提取、总结证据。结果 最终纳入10篇文献，包括1篇临床决策、3篇指南、2篇专家共识、3篇系统评价、1篇证据总结，形成骨髓腔通路建立时机及优势、类型及选择、并发症及预防、使用及培训等4个主题，共24条证据。结论 总结的危重症患者IO的最佳证据包括优势、适应证、禁忌症、并发症及培训等内容，可为临床护理实践提供依据。

Objective To summarize the best evidence for the of intraosseous infusion (IO) management in critically ill patients，and to provide reference for clinical nursing practice.Methods Computer searches were conducted in relevant guideline websites and BMJ Best Clinical Practice，Up To Date，Embase，Cochrane Library，PubMed，CINAHL，China National Knowledge Infrastructure，Wanfang，VIP for guidelines，clinical decisions，evidence summary，expert consensus，and systematic reviews on the IO management in critically ill patients.The search time was from the inceptions to December 2023.Two researchers independently performed literature screening and quality evaluation，and extracted and summarized the evidence according to the theme.Results A total of 10 articles were included，with 1 clinical decision，3 guidelines，2 expert consensus，3 systematic reviews，and 1 evidence summary，which formed a total of 24 pieces of evidence，with 4 topics:timing and advantages of establishment of myeloid access，types and selection，complications and prevention，use and training.Conclusions The best evidence summarized includes advantages，indications，contraindications，complications and training，which can provide a basis for clinical nursing practice.

R472