目的 整合非酒精性脂肪肝患者饮食指导的最佳证据，为临床实践提供依据。方法 根据证据资源“6S”模型，系统检索国内外指南网站、数据库及专业协会网站中关于非酒精性脂肪肝患者饮食指导的所有证据，包括指南、证据总结、专家共识、最佳实践信息册、临床决策、推荐实践、系统评价等，检索时限为建库至2023年4月。采用相应工具对筛选文章进行质量评价，汇总证据条目，评估证据等级。结果 共纳入19篇文献，从减重目标、指导原则、饮食模式、饮食习惯调整、控制食物摄入量、推荐食物品种、热量摄入、饮食比例等8个方面汇总出32条最佳证据。结论 非酒精性脂肪肝患者饮食指导的最佳证据具有科学性与全面性，医护人员可以通过应用最佳证据，指导患者合理饮食，提高干预效果。

Objective To integrate the best evidence on dietary guidance for patients with nonalcoholic fatty liver disease (NAFLD) and to provide reference for improving clinical practice. Methods According to the evidence resource “6S” model,all the evidence on dietary guidance for patients with NAFLD from domestic and foreign guide websites,databases and professional association websites was systematically searched,including guidelines,evidence summary,expert consensus,best practice information book,clinical decision,recommended practice,systematic review,etc. The search time was from the inception to April 2023. The quality of the selected articles was evaluated by corresponding tools,and the evidence items were summarized to evaluate the level of evidence. Results A total of 19 articles on systematic evaluation,expert consensus,and clinical practice guidelines were included,and 32 best evidence items were summarized into 8 categories,namely weight loss goals,guidelines,dietary patterns,dietary habit modification,control of food intake,recommended food varieties,caloric intake,and dietary ratios. Conclusion The best evidence for dietary guidance for patients with NAFLD is scientific and comprehensive.Healthcare staff can apply the best evidence to guide patients to eat reasonably and improve the intervention effects.

R47-05；R473.2

福建省卫生健康创新课题（2021CXB007）；福建医科大学附属第一医院院级课题（2022FY-HZ-20）