目的 探讨脑卒中患者经济毒性的潜在剖面及其影响因素。方法 采用便利抽样法，于2023年3-8月调查上海市某三甲医院的255名脑卒中患者，使用一般资料调查表、患者报告结局的经济毒性综合评分量表、医学应对方式问卷、社会支持评定量表收集数据。运用潜在剖面分析、单因素分析和多元Logistic回归分析确定不同剖面及其影响因素。结果 脑卒中患者经济毒性分为轻度经济毒性组（36.546%）、中度经济毒性风险组（31.727%）和无经济毒性组（31.727%）3个潜在剖面。家庭人均月收入、医疗费用支付方式、合并慢性病数量、改良Rankin评分、面对维度、回避维度、客观支持是脑卒中患者经济毒性潜在剖面的影响因素（均P＜0.05）。结论 脑卒中患者经济毒性水平存在异质性，医护人员应根据脑卒中患者经济毒性不同剖面的分类特征制订针对性的干预措施，以减轻患者的经济毒性。

Objective To explore the potential profile of financial toxicity and its influencing factors among stroke patients.Methods Convenience sampling was employed to investigate 255 stroke patients in a tertiary A hospital in Shanghai from March to August, 2023.Data was collected using the general information questionnaire,Comprehensive Scores for Financial Toxicity Based on the Patient-Reported Outcome Measures,Medical Coping Modes Questionnaire,and Social Support Rating Scale.Latent profile analysis,univariate analysis,and multivariate Logistic regression analysis were used to identify distinct profiles and influencing factors of financial toxicity in stroke patients.Results The Financial toxicity among stroke patients was classified into three latent profiles:“mild financial toxicity group” (36.546%),“moderate financial toxicity risk group” (31.727%),and “no financial toxicity group” (31.727%).The influencing factors of the latent profiles of financial toxicity in stroke patients included household per capita monthly income,method of medical expense payment,number of comorbidities,modified Rankin Scale score,facing dimension,avoidance dimension,and objective support (all P＜0.05).Conclusions There is heterogeneity in the financial toxicity levels among stroke patients.Healthcare professionals should develop targeted intervention measures based on the classification features of different profiles of financial toxicity in stroke patients,aiming to alleviate their financial toxicity.

R473.74

国家自然科学基金面上项目（72074168）