目的 探讨青少年急性白血病化疗患者症状的潜在亚组及网络特征。方法 便利抽样法选取广州市某三级甲等医院化疗的366例青少年急性白血病患者为研究对象，采用一般资料调查表和儿童记忆症状评估量表对其进行问卷调查，采用潜在剖面分析对症状进行分组，采用网络分析揭示各亚组的症状网络结构和核心症状。结果 青少年急性白血病化疗患者的症状分为3个潜在亚组:症状低负担组（42.1%）、症状中负担组（40.7%）和症状高负担组（17.2%）。网络分析显示，症状低负担组的核心症状是焦虑和悲伤，症状中负担组和症状高负担组的核心症状是恶心。结论 青少年急性白血病化疗患者的症状存在群体异质性，可分为3个亚组。临床医护人员应对不同亚组患者的症状特征进行针对性的症状管理。

Objective To identify subgroups and network characteristics of adolescent patients undergoing chemotherapy for acute leukemia (AL).Methods A convenient sample of 366 adolescent patients with AL who underwent chemotherapy at a Children and Women’s Hospital in Guangzhou were surveyed with the general information questionnaire and the Memorial Symptom Assessment Scale.Latent profile analysis was used to classify them into subgroups based on the severity of symptoms.Network analysis was conducted to reveal the network structure of symptoms and identify core symptoms within each subgroup.Results Adolescent patients with AL could be divided into 3 potential subgroups,“low symptom burden subgroup” (42.1%),“medium symptom burden subgroup” (40.7%),and “high symptom burden subgroup” (17.2%).Network analysis revealed that anxiety and sadness were the core symptoms in the low symptom burden subgroup,while nausea emerged as the core symptom in both the medium and high symptom burden subgroups.Conclusions This study demonstrates the existence of population heterogeneity in symptom presentation among adolescent patients with AL,which can be divided into three subgroups.Clinical healthcare professionals should provide personalized care based on the characteristics of symptoms in different subgroups among adolescent patients with AL.

R473.72

广州市卫生健康科技项目(20241A010020)