[关键词]
[摘要]
目的 构建剖宫产新生儿出生6 h内发生低血糖的风险预测模型,为早期识别经剖宫产娩出的新生儿低血糖高危人群提供依据。 方法 2022年1-5月,采用便利抽样法选取在某三级甲等妇幼保健专科医院剖宫产分娩的2456例新生儿为研究对象,将是否发生低血糖分为低血糖组(n=161)和非低血糖组(n=2295)。分析剖宫产新生儿出生6 h内发生低血糖的影响因素,运用Logistic回归构建模型。采用Hosmer-Lemeshow、受试者工作特征曲线下面积(area under curve,AUC)等对模型拟合优度和预测效果评价。 结果 两组新生儿在胎龄、低体重儿、小于胎龄儿、合并先天性心脏病、低体温、红细胞增多症、母亲糖尿病、母亲高血压、母亲术前禁食、母亲产前用药等项目上的差异均有统计学意义(均P<0.05)。早产儿、小于胎龄儿、低体温、先天性心脏病、红细胞增多症、母亲糖尿病、母亲高血压、术前禁食是剖宫产新生儿6 h内发生低血糖的8个独立危险因素。H-L检验χ2为3.014,P为0.884,AUC为0.813,灵敏度为0.795,特异度为0.696,Youden指数为0.491。 结论 构建的模型预测效果良好,可有效预测剖宫产新生儿6h内发生低血糖的风险因素,值得推广应用。
[Key word]
[Abstract]
Objective To construct a risk prediction model of neonatal hypoglycemia by Cesarean section within 6 hours after birth,so as to provide a basis for early identification of neonatal hypoglycemia high-risk population. Methods From January to May 2022,2456 newborns delivered by Cesarean section in a tertiary A women’s hospital were selected by the convivence sampling method.They were divided into hypoglycemia group (n=161) and non-hypoglycemia group (n=2295).To analyze the influencing factors of hypoglycemia in neonates delivered by Cesarean section within 6 hours after birth,and Logistic regression was used to construct a model.Hosmer-Lemeshow and area under the receiver operating characteristic curve (AUC) were used to evaluate the goodness of fit and prediction effect of the model. Results There were significant differences between the 2 groups in gestational age,low birth weight,small for gestational age (SGA),congenital heart disease,hypothermia,polycythemia,maternal diabetes,maternal hypertension,preoperative fasting,and prenatal medication (all P<0.05).There were 8 independent risk factors for neonatal hypoglycemia,including premature infant,SGA,hypothermia,congenital heart disease,polycythemia,maternal diabetes,maternal hypertension and preoperative fasting.H-L test was χ2=3.014,P=0.884,AUC was 0.813,sensitivity was 0.795,specificity was 0.696,and Youden index was 0.491. Conclusion This model has a good prediction effect,which can effectively predict the risk of neonatal hypoglycemia by Cesarean section within 6 hours after birth,and is worthy of promotion and application.
[中图分类号]
R473.72
[基金项目]