目的 探讨老年人久坐行为与衰弱的相关性。方法 计算机检索PubMed、Web of Science、EMbase、The Cochrane Library、知网、万方、中国生物医学数据库和维普等数据库，检索时限为建库以来至2022年6月。所有统计分析均采用R软件进行。结果 最终纳入19篇文献，共9784例患者。Meta分析显示，久坐的老年人衰弱患病率为15%,高水平久坐行为与衰弱或衰弱前期有关。亚组分析显示，加速度计测量的久坐行为，衰弱患病率为7%；问卷等自我报告的形式评估久坐行为，衰弱患病率为23%；量表评估久坐行为，衰弱患病率为12%；身体功能测试评估久坐行为，衰弱患病率为32%（均P＜0.01）。结论 单次连续久坐行为对衰弱的影响更明显，同等时间的身体活动代替久坐行为对衰弱有积极作用。中断久坐行为干预比减少总久坐时间效果更好。年龄、共病、测量工具、久坐时间积累等是影响久坐老年人衰弱的重要因素，未来应该针对这些因素进行更深入的干预。

Objective To investigate the correlation between sedentary behavior (SB) and frailty in the elderly.Methods The literatures were searched from PubMed,Web of Science,Embase,The Cochrane Library,CNKI,Wanfang Data,VIP,and SinoMed with the search period from the inception to June 2022.All statistical analyses were performed with R software.Results Nineteen studies with a total of 9784 patients were included.Meta-analysis showed the prevalence of frailty in the sedentary elderly was 15%.Subgroup analysis showed that the prevalence of debilitation in accelerometer-measured SB was 7%;evaluations in the form of self-report such as questionnaires assessed SB,showed the prevalence of frailty was 23%;evaluation with scale showed the prevalence of frailty was 12%;evaluation with physical function tests showed the prevalence of frailty was 32% (all P＜0.01).Conclusions Through comparative analysis of literature,it was shown that a single continuous SB had a more obvious effect on frailty,and physical activity within the same period instead of SB had a positive effect on frailty.Interrupted SB intervention is better than reducing total sedentary time.The important factors affecting the debilitation of sedentary elderly are age,comorbidity,measurement tool,sedentary time accumulation.More in-depth interventions should be carried out on these factors in the future.

R473.59

国家自然科学基金（72064038）；河南省高校科技创新团队（22IRTSTHN027）