目的 了解腹膜透析患者主观认知下降现状，分析影响因素，并探讨其与衰弱的相关性。方法 2021年8-12月，便利抽样方法选取某三级甲等医院腹膜透析中心规律随访的腹膜透析患者275例为研究对象，应用一般资料调查表、简易智能精神状态量表、主观认知下降问卷、中文版Tilburg衰弱评估量表、主观综合营养评估量表对其进行评估。结果 42.9%（118/275）的患者主观认知下降评分大于3分，存在主观认知下降。年龄、受教育程度、衰弱、营养状况是主观认知下降的影响因素（均P＜0.05）。主观认知下降组和非主观认知下降组衰弱评分差异有统计学意义(P＜0.05)，主观认知下降与衰弱呈正相关（r=0.64,P＜0.001）。结论 腹膜透析患者主观认知下降及衰弱水平均较高，二者相互影响；提示医护人员应加强患者认知和衰弱状况的评估，尽早采取针对性干预措施，减少透析相关并发症，改善患者生活质量。

Objective To study the present situation of the subjective cognition decline of peritoneal dialysis patients,analyze the influencing factors,and explore the correlation between it and frailty.Methods From August 2021 to December 2021,275 peritoneal dialysis patients who were regularly followed up by a level-3 grade-A hospital were selected by convenient sampling method.The patients were assessed by General Information Questionnaire,Simple Intelligent Mental Status Scale,Subjective Cognitive Decline Questionnaire,Tilburg Decline Assessment Scale (Chinese version),and Subjective Comprehensive Nutritional Assessment Scale.Results Among all the subjects,42.9% (118/275) patients showed their subjective cognitive decline scores were greater than 3,indicating a subjective cognitive decline.The influencing factors of subjective cognitive decline were age,education level,frailty,and nutritional status (all P＜0.05).There was a statistically significant difference in the total score of frailty between the SCD group and the non-SCD group (P＜0.05).The decline of subjective cognition was positively correlated with frailty(r=0.64,P＜0.001). Conclusions Peritoneal dialysis patients can show subjective cognitive decline and frailty at a high level,and these two factors affect each other,suggesting that clinical staff should strengthen the assessment of patients’ cognition and frailty and provide targeted interventions as early as possible,to reduce dialysis-related complications and improve their quality of life.

R473.5

苏州市科技发展计划项目（SYSD2020116）