目的 系统评价早产儿达完全经口喂养（full oral feeding，FOF）时间的影响因素。 方法 检索PubMed、Embase、Web of Science、CINAHL 、Cochrane library 、中国知网、万方、维普及中国生物医学文献数据库，系统搜集早产儿达FOF时间影响因素的相关文献。检索时间为从建库至2022年8月10日，按照纳入与排除标准筛选文献并进行质量评价，采用RevMan 5.4和Stata 11软件进行Meta分析。 结果 共纳入15篇文献，包含研究人群4929例。胎龄、 出生体重、分娩方式、开始经口喂养时间、新生儿医学指数（neonatal medical index，NMI）、新生儿口腔运动评定量表（neonatal oral-motor assessment scale，NOMAS）评分、支气管肺发育不良（bronchopulmonary dysplasia，BPD）、动脉导管未闭（patent ductus arteriosus，PDA）、坏死性小肠结肠炎（necrotizing enterocolitis，NEC）、正压呼吸支持时间、袋鼠式护理开始时间以及母亲焦虑、抑郁情况是早产儿达FOF的主要影响因素。 结论 早产儿达FOF时间的影响因素众多，临床护理人员应及时采取措施进行有效地预防和干预， 以帮助早产儿尽快实现FOF，缩短住院时间。

Objective To systematically review the influencing factors of the time for premature infants to achieve full oral feeding（FOF). Methods The databases of PubMed,Embase,Web of Science,CINAHL,Cochrane library,CNKI,Wanfang,VIP and CBM were systematically searched for relevant literature on the influencing factors of the time for premature infants to achieve FOF.The retrieval time frame was from inception to August 10,2022.The literature was screened according to the inclusion and exclusion criteria,and the quality was appraised.The softwares of RevMan 5.4 and Stata 11 were adopted for mata-analysis. Results A total of 15 articles were included,covering 4929 cases of participants.Gestational age,birth weight,mode of delivery,time of initiating oral feeding,NMI,NOMAS score,BPD,PDA,NEC,duration of positive pressure respiratory support,time of initiating kangaroo care,and maternal anxiety and depression were the main influencing factors of the time for premature infants to achieve FOF. Conclusions There are many factors that may influence the time for premature infants to achieve FOF.Clinical nursing staff should timely take measures for effective prevention and intervention,so as to help premature infants achieve FOF as soon as possible,and shorten their length of hospitalization.

R473.72

中华护理学会2020年度立项科研课题（ZHKY202016）