目的 探讨终末期癌症患者发生谵妄的危险因素，为临床医护人员识别高危人群，提前做出干预措施提供参考。 方法 计算机检索Embase、CINAHL、PubMed、中国知网、中国生物医学文献数据库、维普数据库及万方数据库等，搜集与终末期癌症患者发生谵妄的相关文献，检索时间均从建库起至2022年5月8日，使用Revman 5.4.1软件进行统计分析。 结果 共纳入6篇文献，性别[OR=2.39，95% CI (1.32~4.33)，P=0.004]、感染[OR=3.72，95%CI(2.11~6.53)，P＜0.001]、睡眠障碍[OR=4.07，95% CI (3.11~5.33)，P＜0.001]、阿片类药物[OR=1.78，95% CI (1.30~2.43)，P=0.0004]是终末期癌症患者发生谵妄的危险因素，抗生素[OR=0.38，95% CI (0.20~0.71)，P=0.003]是保护因素。 结论 临床医护人员可早期识别终末期癌症患者是否存在谵妄发生的危险因素，提前采取干预措施，以降低谵妄的发生率，提高其终末期生活质量。

Objective To identify the risk factors for delirium in terminal cancer patients,and to provide a reference for clinical medical staff to identify high-risk groups and make intervention measures in advance. Methods Embase,CINAHL,PubMed,CNKI,China Biomedical Literature Database,VIP database and Wanfang Database were searched by computer to collect literature related to delirium in terminal cancer patients.The search time was from the inceptions to May 8,2022.Statistical analysis was performed using Revman 5.4.1 software. Results A total of six articles were included,with gender[OR=2.39,95%CI(1.32-4.33),P=0.004],infection[OR=3.72,95%CI(2.11-6.53),P＜0.001],sleep disorders[OR=4.07,95%CI(3.11-5.33),P＜0.001],opioids[OR=1.78,95%CI(1.30-2.43),P=0.0004] as the risk factors for delirium in terminal cancer patients,while with antibiotics[OR=0.38,95%CI(0.20-0.71),P=0.003] as the protective factor. Conclusions Clinical medical staff can identify whether there are risk factors for delirium in terminal cancer patients, take intervention measures in advance to reduce the incidence of delirium,and improve their quality of life.

R473;R47-05

湖南省自然科学基金资助项目（2021JJ40319）