目的 检索、评价和整合成人肠内营养患者鼻肠管堵管预防及处理的最佳证据，为临床提供参考。 方法 系统检索指南网站、数据库、营养协会网站中关于成人鼻肠管堵管预防与处理的所有中、英文证据，包括指南、专家共识、系统评价、证据总结、推荐实践以及随机对照研究。检索时限为建库至2022年5月21日。 结果 共纳入19篇文献，提取了33条证据，包括成立多学科堵管防控小组，鼻肠管选择及留置，营养制剂种类、温度及泵入速度，冲管时机、溶液、工具及技巧，给药原则及方法，无菌原则，营养泵管理及堵管后处理8个方面。 结论 成人肠内营养患者鼻肠管堵管预防及处理的最佳证据，可为规范医护人员鼻肠管堵管预防及处理措施提供循证依据。

Objective To search,evaluate and summarize the best evidence for prevention and management of nasointestinal tube obstruction in adult patients with enteral nutrition,and to provide reference for clinical treatment. Methods The guideline websites,academic databases and nutrition-related academic websites were searched for the literature related to occlusion with nasointestinal tubes.All the evidences in English and Chinese were searched,including guidelines,expert consensus,systematic reviews,summaries of evidence,recommended practices,and randomized controlled studies.The retrieval period is from the inception to May 21th,2022. Results A total of 19 articles were included.A total of 33 pieces of best evidence were obtained and divided into 8 categories including establishment of MDT team,nasoenteric tube selection and indwelling,the selection and pumping speed of nutritional preparations,nutrient preparation type,temperature and pumping speed,the timing of flushing tubes,solutions,tools and techniques,principles and methods of administration,aseptic principles,nutrition pump management and post-clogging. Conclusions The best evidence for prevention and management of occlusion with adults patients with enteral nutrition were summarized,which can provide evidence-based basis for standardizing prevention and treatment measures of nasointestinal tube occlusion in medical staff.

R47

2021年河南省医学科技攻关联合共建项目（LHG20210220）