目的 探究二元应对干预对高级别脑胶质瘤患者及其配偶心理困扰和生活质量的影响，以期为提升其应对疾病能力及生活质量提供现实依据。 方法 2021年1-12月，采用便利抽样法选取某院收治的高级别脑胶质瘤患者及其配偶42对作为研究组，并回顾性分析2020年1-12月收治的高级别脑胶质瘤患者及其配偶42对的病例资料作为对照组。对照组采用常规护理方法，研究组在常规护理基础上采用二元应对干预措施。比较两组患者的心理困扰程度及生活质量。 结果 研究组脑胶质瘤患者及其配偶心理困扰评分低于对照组，而生活质量得分高于对照组，差异均有统计学意义（均P＜0.05）。 结论 二元应对干预不仅可以促进高级别脑胶质瘤患者及其配偶的身心健康，而且能够提升其生活质量，值得推广。

Objective To explore the effect of binary coping intervention on the psychological distress and quality of life(QOL) of patients with high-grade glioma and their spouses. Methods From January to December 2021,42 pairs of high-grade glioma patients and their spouses from a hospital were selected as the study group by the convenience sampling method,and the case data of 42 pairs of high-grade glioma patients and their spouses from January to December 2020 were retrospectively analyzed as the control group.The control group received conventional nursing,while the study group received binary coping interventions based on conventional nursing.The degree of psychological distress and QOL were compared between the two groups. Results The psychological distress scores of glioma patients and their spouses in the study group were lower than those in the control group,while the QOL scores were higher than those in the control group,with statistical significance(all P＜0.05). Conclusions Binary coping intervention can not only promote the physical and mental health of high-grade glioma patients and their spouses,but also improve the QOL of patients and their spouses,which is worthy of clinical promotion.

R473.2;471

上海周良辅医学发展基金会“华山医院专科护理支持项目”（XM00025-2020-4）